Journal: Journal of Veterinary Internal Medicine
Article Title: Comparison of 2 assays for measuring serum total thyroxine concentration in dogs and cats
doi: 10.1111/jvim.15703
Figure Lengend Snippet: A, Passing‐Bablok regression line of feline CTT4 versus MTT4 is shown but the assumption of linearity was violated. Piecewise regression analysis yielded a slope of 1.25 (95% CI, 0.93‐1.56) indicating a tendency to overestimate TT4 concentration until the MTT4 breakpoint of 1.80 μg/dL (95% CI, 0.94‐2.66 μg/dL) [23.17 nmol/L; 95% CI, 12.10‐34.24 nmol/L). The second linear segment from 1.80 μg/dL [23.17 nmol/L) had a slope of 0.94 (95% CI, 0.93‐0.96), indicating proportional bias with subsequent underestimation of TT4 concentrations. B, Bland‐Altman plot of CTT4 versus MTT4 for cats. The solid line represents the mean difference (0.10 μg/dL [1.29 nmol/L]) and the dashed lines represent the mean difference ±1.96 SD (−1.19‐1.30 μg/dL [−15.32‐16.73 nmol/L]). CI, confidence interval; CTT4, Catalyst Total T4 Test; MTT4, Microgenics DRI human TT4 EIA assay
Article Snippet: A novel dry‐slide TT4 assay (CTT4; Catalyst Total T4 Test, IDEXX Laboratories, Inc, Westbrook, Maine) recently was introduced for in‐clinic use using 2 bench top point‐of‐care analyzers (IDEXX Catalyst One Analyzer [C1]; IDEXX Catalyst Dx Analyzer [CDx]).
Techniques: Concentration Assay, Enzyme Immunoassay